No Federalism on the Right highlights an interesting issue:
For decades, liberals scoffed at federalist arguments that the people of Wisconsin or Wyoming understood their own needs better than a distant Congress. They brought more and more power to Washington, over-riding state legislatures and imposing mandates on every nook and cranny of governance.
Now those chickens have come home to roost. Republicans run Washington, and they're using the federal power that liberals built in ways that liberals never envisioned.
I think there is definitely a long term re-alignment of power in the US. Perhaps issues such as isolationism, fiscal responsibility and states rights can really only belong to an opposition party.